Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dopamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.78 |
| ▸ | MAPT | P10636 | 4/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.78 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.78 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.78 |
| ▸ | DRD2 | P14416 | 2/20 | 0.78 |
| ▸ | DRD1 | P21728 | 2/20 | 0.78 |
| ▸ | DRD4 | P21917 | 2/20 | 0.78 |
| ▸ | DRD5 | P21918 | 2/20 | 0.78 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.78 |
| ▸ | DRD3 | P35462 | 2/20 | 0.78 |
| ▸ | RECQL | P46063 | 2/20 | 0.78 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.78 |
| ▸ | APEX1 | P27695 | 2/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.78 |
| ▸ | TP53 | P04637 | 2/20 | 0.78 |
| ▸ | THPO | P40225 | 2/20 | 0.78 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dopamine SCHEMBL27987867 | 0.88 | MAPK1 (0.91) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL16685137 | 0.88 | KDM4E (1.00) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL8505 | 0.88 | KDM4E (1.00) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL29375089 | 0.88 | KDM4E (1.00) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL496657 | 0.88 | KDM4E (1.00) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL18159501 | 0.88 | KDM4E (1.00) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL9166387 | 0.88 | KDM4E (1.00) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL29362033 | 0.88 | KDM4E (1.00) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL30379944 | 0.88 | KDM4E (1.00) | MAPK1MAPTKDM4ETAAR1ALOX15 | |
| Dopamine SCHEMBL27733339 | 0.86 | MAPK1 (0.88) | MAPK1MAPTKDM4ETAAR1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114010510-B | Dentin bonding pretreatment composition based on DMA (direct memory access) and application thereof | 中国人民解放军总医院第一医学中心 | 2023-05-05 | — | — | CN | claimed |
| CN-114010510-B | Dentin bonding pretreatment composition based on DMA (direct memory access) and application thereof | 中国人民解放军总医院第一医学中心 | 2023-05-05 | — | — | CN | disclosed |