Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.31 |
| ▸ | CHUK | O15111 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17967357 | 0.89 | SIGMAR1 (0.38) | SIGMAR1JAK2P2RX7NAMPTPIK3CD | |
| SCHEMBL871452 | 0.81 | SIGMAR1 (0.39) | SIGMAR1JAK2P2RX7NAMPTPIK3CD | |
| SCHEMBL30749810 | 0.81 | SIGMAR1 (0.39) | SIGMAR1JAK2P2RX7NAMPTPIK3CD | |
| SCHEMBL31291536 | 0.79 | SIGMAR1 (0.37) | SIGMAR1JAK2P2RX7NAMPTCYP3A4 | |
| SCHEMBL30945101 | 0.76 | SIGMAR1 (0.38) | SIGMAR1JAK2NAMPTPRMT5ROCK2 | |
| SCHEMBL28861111 | 0.75 | SLC22A12 (0.43) | JAK2P2RX7PRMT5 | |
| SCHEMBL13058244 | 0.75 | SIGMAR1 (0.48) | SIGMAR1JAK2PIK3CDCYP3A4PRMT5 | |
| SCHEMBL24205668 | 0.75 | SIGMAR1 (0.44) | SIGMAR1JAK2P2RX7PRMT5JAK3 | |
| SCHEMBL13286026 | 0.73 | SIGMAR1 (0.38) | SIGMAR1JAK2P2RX7PIK3CD | |
| SCHEMBL10222870 | 0.72 | SIGMAR1 (0.45) | SIGMAR1P2RX7PRMT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115856141-A | Method for separating and determining tinib key intermediate and related impurities thereof by HPLC | 上海博悦生物科技有限公司 | 2023-03-28 | — | — | CN | disclosed |