Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 8/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NNMT | P40261 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28394729 | 0.87 | SLC22A12 (0.40) | SLC22A12FGFR1FGFR4RAF1BRAF | |
| SCHEMBL31720885 | 0.78 | SLC22A12 (0.41) | SLC22A12FGFR1FGFR4POLBGAA | |
| SCHEMBL1897615 | 0.78 | SLC22A12 (0.41) | SLC22A12FGFR1FGFR4POLBGAA | |
| SCHEMBL27870994 | 0.78 | MGAM (0.34) | GAA | |
| SCHEMBL28029825 | 0.78 | ATR (0.33) | POLBKMT2ATDP1 | |
| SCHEMBL27620896 | 0.77 | GPR119 (0.42) | SLC22A12FGFR1FGFR4NNMTPRMT5 | |
| SCHEMBL29210053 | 0.76 | SLC22A12 (0.39) | SLC22A12FGFR1FGFR4NNMTNPC1 | |
| SCHEMBL28995145 | 0.75 | SIGMAR1 (0.38) | PRMT5JAK2P2RX7 | |
| SCHEMBL30749813 | 0.75 | SLC22A12 (0.39) | SLC22A12FGFR1FGFR4KMT2AL3MBTL1 | |
| SCHEMBL3708799 | 0.72 | SLC22A12 (0.52) | SLC22A12FGFR1FGFR4KDRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116678973-A | High performance liquid chromatography analysis and detection method for robustatinib intermediate and impurities | 安徽大学 | 2023-09-01 | — | — | CN | claimed |
| CN-115028638-A | Preparation method of ruxotinib intermediate | 安徽大学 | 2022-09-09 | — | — | CN | claimed |
| CN-115181103-B | Preparation method of barytinib | 上海博悦生物科技有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-115181103-B | Preparation method of barytinib | 上海博悦生物科技有限公司 | 2023-11-07 | — | — | CN | disclosed |
| CN-116678973-A | High performance liquid chromatography analysis and detection method for robustatinib intermediate and impurities | 安徽大学 | 2023-09-01 | — | — | CN | disclosed |
| CN-115181103-A | Preparation method of barretinib | 上海博悦生物科技有限公司 | 2022-10-14 | — | — | CN | disclosed |
| CN-115028638-A | Preparation method of ruxotinib intermediate | 安徽大学 | 2022-09-09 | — | — | CN | disclosed |