SCHEMBL28995174

SCHEMBL28995174

CC1Cc2cc(Br)ccc2N(Cc2ccccc2)C1=O

nearest known ligand 0.53

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.53
ALDH2 P05091 2/20 0.53
ALDH3A1 P30838 2/20 0.53
XIAP P98170 1/20 0.45
BRD4 O60885 1/20 0.43
ACHE P22303 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
POLB P06746 2/20 0.42
KMT2A Q03164 4/20 0.41
MEN1 O00255 3/20 0.41
TP53 P04637 1/20 0.41
MAPT P10636 1/20 0.41
SIGMAR1 Q99720 1/20 0.41
NPC1 O15118 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30489385 1.00 ALDH1A1 (0.53) ALDH1A1ALDH2ALDH3A1XIAPBRD4
SCHEMBL28995163 0.86 ALDH1A1 (0.49) ALDH1A1ALDH2ALDH3A1POLBKMT2A
SCHEMBL28995171 0.86 KMT2A (0.52) ALDH1A1POLBKMT2AMEN1
SCHEMBL30489354 0.86 ALDH1A1 (0.49) ALDH1A1ALDH2ALDH3A1POLBKMT2A
SCHEMBL30489297 0.86 KMT2A (0.52) ALDH1A1POLBKMT2AMEN1
SCHEMBL31398271 0.85 PARK7 (0.46) ALDH1A1ACHEHDAC1HDAC8HDAC6
SCHEMBL650181 0.85 ALDH1A1 (0.53) ALDH1A1ALDH2ALDH3A1XIAPBRD4
SCHEMBL5134148 0.85 ALDH1A1 (0.53) ALDH1A1ALDH2ALDH3A1XIAPBRD4
SCHEMBL30489346 0.85 KMT2A (0.47) POLBKMT2AMEN1SIGMAR1
SCHEMBL28995172 0.85 KMT2A (0.47) POLBKMT2AMEN1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116043243-A Method for electrochemically synthesizing 3, 4-dihydro-quinolinone compounds 桂林电子科技大学 2023-05-02 CN disclosed