Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.38 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | LSS | P48449 | 2/20 | 0.35 |
| ▸ | FABP4 | P15090 | 2/20 | 0.34 |
| ▸ | FABP5 | Q01469 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28995466 | 0.82 | EGLN1 (0.39) | EGLN1KMOLSSFABP4FABP5 | |
| SCHEMBL29946884 | 0.81 | LMNA (0.36) | PDGFRACDK5TYRO3HSD17B10MEN1 | |
| SCHEMBL23538386 | 0.81 | LMNA (0.36) | PDGFRACDK5TYRO3HSD17B10MEN1 | |
| SCHEMBL31330992 | 0.76 | EGLN1 (0.41) | EGLN1KMOLSSPDGFRACDK5 | |
| SCHEMBL28995524 | 0.72 | RXFP1 (0.54) | EGLN1KMOPDGFRACDK5TYRO3 | |
| SCHEMBL31323548 | 0.70 | EGLN1 (0.42) | EGLN1KMOLSSPDGFRACDK5 | |
| SCHEMBL22119625 | 0.68 | APEX1 (0.46) | EGLN1KMOPDGFRACDK5TYRO3 | |
| SCHEMBL29976679 | 0.68 | APEX1 (0.46) | EGLN1KMOPDGFRACDK5TYRO3 | |
| SCHEMBL15332426 | 0.68 | PDGFRA (0.39) | LSSPDGFRACDK5TYRO3MEN1 | |
| SCHEMBL23551752 | 0.67 | PDGFRA (0.34) | EGLN1KMOLSSPDGFRACDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117440813-A | EGFR degrading agents for treating brain or CNS cancer metastasis | C4医药公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-115996719-A | BRAF degradation agent | C4医药公司 | 2023-04-21 | — | — | CN | disclosed |
| CN-114901277-A | Isoindolinone and indazole compounds for EGFR degradation | C4医药公司 | 2022-08-12 | — | — | CN | disclosed |