SCHEMBL31330992

SCHEMBL31330992

Cn1nc(N(CCC(=O)O)C(N)=O)c2ccc(Br)cc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
EGLN1 Q9GZT9 2/20 0.41
KMO O15229 2/20 0.40
PDGFRA P16234 1/20 0.39
CDK5 Q00535 1/20 0.39
TYRO3 Q06418 1/20 0.39
LSS P48449 1/20 0.34
TBXAS1 P24557 1/20 0.33
GAA P10253 2/20 0.32
KDM4E B2RXH2 1/20 0.32
ALDH1A1 P00352 1/20 0.32
GPR17 Q13304 1/20 0.32
APEX1 P27695 1/20 0.32
ELANE P08246 1/20 0.32
HDAC8 Q9BY41 1/20 0.31
CASP3 P42574 1/20 0.31
RXFP1 Q9HBX9 2/20 0.31
CRHBP P24387 1/20 0.31
CRHR2 Q13324 1/20 0.31
MAPT P10636 1/20 0.31
F2 P00734 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28995466 0.92 EGLN1 (0.39) EGLN1KMOPDGFRACDK5TYRO3
SCHEMBL31330812 0.90 KDM4E (0.39) EGLN1PDGFRACDK5TYRO3LSS
SCHEMBL26621431 0.86 PDGFRA (0.39) EGLN1KMOPDGFRACDK5TYRO3
SCHEMBL23538992 0.86 LMNA (0.36) PDGFRACDK5TYRO3ALDH1A1ELANE
SCHEMBL23551375 0.82 LMNA (0.38) PDGFRACDK5TYRO3LSSGAA
SCHEMBL26621498 0.78 AAK1 (0.37) EGLN1PDGFRACDK5TYRO3LSS
SCHEMBL26621592 0.76 GAA (0.36) EGLN1KMOPDGFRACDK5TYRO3
SCHEMBL28995449 0.76 EGLN1 (0.38) EGLN1KMOPDGFRACDK5TYRO3
SCHEMBL22119625 0.73 APEX1 (0.46) EGLN1KMOPDGFRACDK5TYRO3
SCHEMBL29976679 0.73 APEX1 (0.46) EGLN1KMOPDGFRACDK5TYRO3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025011623-A1 CYANOQUINOLINE-TARGETING PROTEIN DEGRADATION MOLECULE, PREPARATION METHOD THEREFOR AND USE THEREOF 上海壹迪生物技术有限公司 2025-01-16 WO disclosed