SCHEMBL2899732

SCHEMBL2899732

Nc1nc2cc(Cl)c(Cl)cc2s1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.59
SMN1; SMN2 Q16637 3/20 0.59
CYP3A4 P08684 3/20 0.59
TP53 P04637 1/20 0.59
TSHR P16473 1/20 0.59
RAB9A P51151 3/20 0.50
GAA P10253 2/20 0.50
MAPT P10636 1/20 0.50
AXL P30530 1/20 0.50
GFER P55789 1/20 0.50
HTT P42858 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
DRD2 P14416 2/20 0.49
CYP1A2 P05177 2/20 0.48
CYP2D6 P10635 1/20 0.48
NPC1 O15118 2/20 0.46
SCN4A P35499 2/20 0.46
LMNA P02545 2/20 0.46
EPHX2 P34913 1/20 0.46
KDM4E B2RXH2 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29462442 1.00 ALDH1A1 (0.59) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
Nitrogen SCHEMBL27684908 0.96 ALDH1A1 (0.55) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
SCHEMBL26927659 0.84 SMN1; SMN2 (0.72) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
SCHEMBL16238119 0.84 SMN1; SMN2 (0.72) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
SCHEMBL10201412 0.84 ALDH1A1 (0.52) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
SCHEMBL1638626 0.84 AXL (0.53) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
SCHEMBL9885168 0.84 SMN1; SMN2 (0.71) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
SCHEMBL8410729 0.83 SMN1; SMN2 (0.47) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
Pyrazole SCHEMBL28081671 0.82 TP53 (0.42) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR
SCHEMBL9963480 0.81 SMN1; SMN2 (0.68) ALDH1A1SMN1; SMN2CYP3A4TP53TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 205 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114960229-A Tent cloth dyeing process 圣山集团有限公司 2022-08-30 CN claimed
CN-113968796-A Preparation method of azo dye with excellent environment-friendly application performance 安徽清科瑞洁新材料有限公司 2022-01-25 CN claimed
CN-109535044-B Diazotization method of aromatic primary amine 金华双宏化工有限公司 2021-06-15 CN claimed
CN-112500713-A Continuous preparation method of azo disperse dye 浙江龙盛染料化工有限公司 2021-03-16 CN claimed
CN-111077145-A Method for determining and/or controlling conversion rate of diazotization reaction of aromatic amine in continuous production 沈阳化工研究院有限公司 2020-04-28 CN claimed
CN-107963617-B A kind of production method and system of nitrosyl sulfuric acid ZHEJIANG DIBANG CHEMICAL CO., LTD. (CN) 2019-11-01 CN claimed
CN-107892824-B A kind of preparation method of environment-friendly type azo dispersion dyes 浙江闰土研究院有限公司 2019-05-17 CN claimed
CN-109535044-A A kind of diazotisation methods of primary aromatic amine 金华双宏化工有限公司 2019-03-29 CN claimed
CN-103664683-B A kind of continuous diazotising production technology of aromatic amine 浙江龙盛集团股份有限公司 2018-05-11 CN claimed
CN-107963617-A The production method and system of a kind of nitrosyl sulfuric acid 浙江迪邦化工有限公司 2018-04-27 CN claimed
CN-107892824-A A kind of preparation method of environment-friendly type azo dispersion dyes 浙江闰土研究院有限公司 2018-04-10 CN claimed
CN-105860570-A Halogenated benzothiazole-azo disperse dye monomer compounds, and preparation method and application thereof 俞杏英 2016-08-17 CN claimed
CN-104231659-A Red thiazole heterocyclic disperse dye compound containing benzoate group and preparation and application thereof YU XINGYING 2014-12-24 CN claimed
CN-101857579-B Synthesis method of 2-amino-5,6-dichlorobenzothiazole UNIV ZHEJIANG TECHNOLOGY 2012-07-25 CN claimed
CN-101857579-A Synthesis method of 2-amino-5,6-dichlorobenzothiazole UNIV ZHEJIANG TECHNOLOGY 2010-10-13 CN claimed
JP-63161058-A None JP disclosed
JP-8060006-A None JP disclosed
US-3950321-A POLYESTERS BASF AKTIENGESELLSCHAFT (DT) 1976-04-13 US disclosed
US-3950130-A THIAZOLE-AZO DYES AND THE COLORATION OF POLYESTER TEXTILE FIBERS THEREWITH AMERICAN ANILINE PRODUCTS, INC. (US) 1976-04-13 US disclosed
US-3931145-A POLYESTER GAF CORPORATION (US) 1976-01-06 US disclosed