SCHEMBL28998735

SCHEMBL28998735

Cn1nnc(-c2ncc(NC(=O)OC(C)(C)C)cn2)c1OC(N)=O

nearest known ligand 0.36

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 1/20 0.36
NAMPT P43490 1/20 0.35
PRMT1 Q99873 1/20 0.34
MAPKAPK2 P49137 6/20 0.34
RORC P51449 5/20 0.34
BCL2 P10415 1/20 0.34
CYP17A1 P05093 2/20 0.33
MAP4K4 O95819 1/20 0.33
GSK3B P49841 1/20 0.32
DYRK1A Q13627 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28998178 0.86 BCL2 (0.41) MAPK14NAMPTPRMT1MAPKAPK2RORC
SCHEMBL28998186 0.83 CYP17A1 (0.45) MAPK14NAMPTPRMT1BCL2CYP17A1
SCHEMBL29153849 0.81 MAPK14 (0.36) MAPK14NAMPTPRMT1MAPKAPK2RORC
SCHEMBL24867893 0.81 MAPK14 (0.38) MAPK14NAMPTMAPKAPK2RORCBCL2
SCHEMBL28998169 0.81 GSK3B (0.37) NAMPTMAPKAPK2BCL2GSK3BDYRK1A
SCHEMBL28998741 0.79 RAB9A (0.50)
SCHEMBL28998161 0.78 MEN1 (0.31)
SCHEMBL28998228 0.77 CYP17A1 (0.35) RORCCYP17A1GSK3BDYRK1A
Hydrochloric Acid SCHEMBL28998246 0.77 MEN1 (0.31)
SCHEMBL28998255 0.76 BACE1 (0.33)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115942972-A LPA receptor antagonists and uses thereof 吉利德科学公司 2023-04-07 CN disclosed