SCHEMBL28998741

SCHEMBL28998741

Cn1nnc(-c2ncc(NC(=O)c3ccc(Cl)nc3)cn2)c1OC(N)=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 4/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
KCNQ3 O43525 11/20 0.44
KCNQ2 O43526 11/20 0.44
KCNE1 P15382 7/20 0.44
KCNQ1 P51787 7/20 0.44
MEN1 O00255 4/20 0.43
KMT2A Q03164 4/20 0.43
ALDH1A1 P00352 1/20 0.43
LMNA P02545 1/20 0.43
BACE1 P56817 1/20 0.43
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
CYP2C9 P11712 1/20 0.42
CYP2C19 P33261 1/20 0.42
MAPT P10636 4/20 0.41
POLB P06746 2/20 0.41
TDP1 Q9NUW8 1/20 0.41
PKM P14618 1/20 0.40
NPC1 O15118 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28998729 0.87 KCNQ3 (0.48) RAB9ASMN1; SMN2KCNQ3KCNQ2KCNE1
SCHEMBL28998221 0.83 KMT2A (0.42) RAB9ASMN1; SMN2KCNQ3KCNQ2KCNE1
SCHEMBL28998735 0.79 MAPK14 (0.36)
SCHEMBL29184125 0.78 TRPV1 (0.42) SMN1; SMN2MEN1KMT2AALDH1A1LMNA
SCHEMBL28998161 0.75 MEN1 (0.31) MEN1KMT2A
SCHEMBL28998201 0.75 KCNQ3 (0.38) RAB9ASMN1; SMN2KCNQ3KCNQ2KCNE1
SCHEMBL28998796 0.74 PTPN1 (0.51) RAB9ASMN1; SMN2KCNQ3KCNQ2KCNE1
Hydrochloric Acid SCHEMBL28998246 0.74 MEN1 (0.31) MEN1KMT2A
SCHEMBL28998255 0.73 BACE1 (0.33) BACE1
SCHEMBL28998740 0.71 KDM4E (0.37) RAB9ASMN1; SMN2MEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115942972-A LPA receptor antagonists and uses thereof 吉利德科学公司 2023-04-07 CN disclosed