Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.37 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28999956 | 0.91 | MAPT (0.42) | MAPTGAAHTTLMNAALDH1A1 | |
| SCHEMBL30363107 | 0.91 | MAPT (0.42) | MAPTGAAHTTLMNAALDH1A1 | |
| SCHEMBL8072110 | 0.84 | ALDH1A1 (0.44) | MAPTLMNAALDH1A1KMT2AMEN1 | |
| SCHEMBL3341502 | 0.79 | VCAM1 (0.48) | MAPTGAALMNAALDH1A1KMT2A | |
| SCHEMBL30803845 | 0.79 | VCAM1 (0.48) | MAPTGAALMNAALDH1A1KMT2A | |
| SCHEMBL2464904 | 0.78 | TDP1 (0.46) | MAPTHTTLMNAALDH1A1KMT2A | |
| SCHEMBL3343914 | 0.78 | MEN1 (0.57) | MAPTGAALMNAALDH1A1KMT2A | |
| SCHEMBL29271622 | 0.77 | SMN1; SMN2 (0.46) | MAPTGAAHTTLMNAALDH1A1 | |
| SCHEMBL28999954 | 0.77 | MAPT (0.46) | MAPTGAALMNAALDH1A1KMT2A | |
| SCHEMBL28999953 | 0.77 | TDP1 (0.49) | MAPTLMNAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116075512-A | Heterocyclic compounds and imaging agents for imaging huntingtin | CHDI基金会股份有限公司 | 2023-05-05 | — | — | CN | disclosed |
| EP-4165044-A1 | HETEROCYCLIC COMPOUNDS AND IMAGING AGENTS FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2023-04-19 | — | — | EP | disclosed |