Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | KMO | O15229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203710 | 0.83 | CLK1 (0.43) | ROCK2NAMPTALDH1A1HPGDMAPT | |
| SCHEMBL2899563 | 0.83 | NTRK1 (0.41) | KDM4EALDH1A1MAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL1203652 | 0.79 | MEN1 (0.43) | FYNKDM4EALDH1A1HPGDMAPT | |
| SCHEMBL1203223 | 0.77 | KMT2A (0.46) | ALDH1A1HPGDMAPTRXFP1SMN1; SMN2 | |
| SCHEMBL1203562 | 0.76 | MAPT (0.41) | MAPTRXFP1SMN1; SMN2HSD17B10 | |
| SCHEMBL21637243 | 0.73 | HTT (0.47) | KDM4EALDH1A1MAPTRXFP1GAA | |
| SCHEMBL14896984 | 0.71 | AAK1 (0.44) | ADRA1AIRAK4 | |
| SCHEMBL16243753 | 0.71 | AAK1 (0.44) | ADRA1AIRAK4 | |
| SCHEMBL18208326 | 0.70 | DYRK1A (0.50) | FYNKDM4EHPGDHSD17B10TDP1 | |
| SCHEMBL17541808 | 0.70 | TIPARP (0.48) | TIPARPROCK2ESR1ESR2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |