Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 3/20 | 0.41 |
| ▸ | DRD5 | P21918 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.39 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17541791 | 0.84 | GRM5 (0.40) | TIPARP | |
| SCHEMBL24667446 | 0.78 | MCHR1 (0.33) | TIPARPMAPTLMNA | |
| SCHEMBL29987748 | 0.78 | NPC1 (0.44) | PDE3BPDE3ASMN1; SMN2METAP1 | |
| SCHEMBL24667588 | 0.78 | NPC1 (0.44) | PDE3BPDE3ASMN1; SMN2METAP1 | |
| SCHEMBL23562064 | 0.77 | GRM5 (0.42) | TIPARPDRD1DRD5HRH3 | |
| SCHEMBL3902560 | 0.70 | DRD1 (0.65) | DRD1DRD5MAPTLMNADRD2 | |
| SCHEMBL2900291 | 0.70 | TIPARP (0.41) | TIPARPMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL16637778 | 0.68 | ROCK2 (0.53) | TIPARPDRD1DRD5MAPTLMNA | |
| SCHEMBL15880544 | 0.67 | ESR1 (0.57) | ESR1ESR2 | |
| SCHEMBL30677763 | 0.67 | ESR1 (0.57) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036291-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12036291-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| CN-118005611-A | Probes for imaging huntingtin | CHDI基金会股份有限公司 | 2024-05-10 | — | — | CN | disclosed |
| CN-107074817-B | Probes for imaging huntingtin | CHDI基金会股份有限公司 | 2023-12-15 | — | — | CN | disclosed |
| US-20210379211-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. | 2021-12-09 | — | — | US | disclosed |
| US-11071793-B2 | Probes for imaging huntingtin protein | CHDI FOUNDATION, INC. (US) | 2021-07-27 | — | — | US | disclosed |
| EP-3186241-B1 | PROBES FOR IMAGING HUNTINGTON PROTEIN | CHDI FOUNDATION INC (US) | 2020-10-07 | — | — | EP | disclosed |
| US-20170281804-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | EVOTEC (UK) LTD. (GB) | 2017-10-05 | — | — | US | disclosed |
| US-20170281804-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | EVOTEC (UK) LTD. (GB) | 2017-10-05 | — | — | US | disclosed |
| US-20170281804-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | EVOTEC (UK) LTD. (GB) | 2017-10-05 | — | — | US | disclosed |
| EP-3186241-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI Foundation, Inc. (US) | 2017-07-05 | — | — | EP | disclosed |
| WO-2016033436-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | CHDI FOUNDATION, INC. (US) | 2016-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210379211-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | TIPARP 2113/4885PDE3B 4170/4885PDE3A 3875/4885 |
| US-11071793-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | TIPARP 2113/4885PDE3B 4170/4885PDE3A 3875/4885 |
| US-20170281804-A1 | PROBES FOR IMAGING HUNTINGTIN PROTEIN | HTT, HYPK, HSPBP1 | TIPARP 2113/4885PDE3B 4170/4885PDE3A 3875/4885 |
| US-12036291-B2 | Probes for imaging huntingtin protein | HTT, HYPK, HSPBP1 | TIPARP 2113/4885PDE3B 4170/4885PDE3A 3875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.