Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.50 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | JAK1 | P23458 | 5/20 | 0.43 |
| ▸ | JAK3 | P52333 | 5/20 | 0.43 |
| ▸ | CDK2 | P24941 | 5/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30445086 | 0.98 | KCNH2 (0.50) | KCNH2CDK6JAK2JAK1JAK3 | |
| SCHEMBL28679680 | 0.91 | KCNH2 (0.43) | KCNH2CDK6JAK2JAK1JAK3 | |
| Ammonia Solution, Strong SCHEMBL29005340 | 0.85 | CDK9 (0.46) | KCNH2CDK2MAPK8GSK3BCAMKK2 | |
| Ammonia Solution, Strong SCHEMBL29005335 | 0.83 | CDK4 (0.50) | KCNH2CDK6JAK2JAK1JAK3 | |
| SCHEMBL30445546 | 0.83 | CDK9 (0.46) | KCNH2CDK2MAPK8GSK3BCAMKK2 | |
| Ammonia Solution, Strong SCHEMBL29005328 | 0.83 | CDK4 (0.49) | KCNH2CDK6JAK2JAK1JAK3 | |
| SCHEMBL30445224 | 0.82 | CDK4 (0.50) | KCNH2CDK6JAK2JAK1JAK3 | |
| SCHEMBL30445681 | 0.81 | CDK4 (0.49) | KCNH2CDK6JAK2JAK1JAK3 | |
| SCHEMBL28714810 | 0.69 | JAK2 (0.48) | KCNH2JAK2JAK3CDK2GSK3B | |
| SCHEMBL28679677 | 0.69 | CSF1R (0.58) | KCNH2CDK6CDK2CDK1CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113999210-B | Group of 2-phenylamino-4-triazolyl pyrimidine derivatives and application thereof | 郑州大学第一附属医院 | 2023-05-23 | — | — | CN | claimed |