SCHEMBL29005338

SCHEMBL29005338

CC(C)(C)OC(=O)NC(C(=O)O)C(=O)NC(c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S1PR3 Q99500 2/20 0.51
PPARG P37231 1/20 0.46
PPARA Q07869 1/20 0.46
ALDH1A1 P00352 2/20 0.42
MAPT P10636 2/20 0.42
TRPA1 O75762 1/20 0.42
CNR1 P21554 4/20 0.42
CTSS P25774 1/20 0.41
CTSK P43235 1/20 0.41
PRCP P42785 2/20 0.40
CTSL P07711 1/20 0.39
GAA P10253 2/20 0.39
P2RY2 P41231 1/20 0.38
ATM Q13315 1/20 0.38
CACNA1B Q00975 1/20 0.38
LMNA P02545 1/20 0.38
TSHR P16473 1/20 0.38
KDM4E B2RXH2 1/20 0.38
PKM P14618 1/20 0.38
HPGD P15428 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29005173 0.85 ALDH1A1 (0.54) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL4277192 0.79 S1PR3 (0.53) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL4289099 0.79 S1PR3 (0.53) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL999536 0.79 S1PR3 (0.53) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL6443317 0.77 PPARA (0.48) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL23205818 0.76 PPARG (0.47) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL20521905 0.76 PPARG (0.47) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL3824377 0.76 TRPA1 (0.49) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL5862822 0.76 PPARG (0.47) S1PR3PPARGPPARAALDH1A1MAPT
SCHEMBL2836398 0.76 TRPA1 (0.52) S1PR3PPARGPPARAALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116134018-A 2-oxoimidazolidine-4-carboxamide as NAV1.8 inhibitor 默沙东有限责任公司 2023-05-16 CN disclosed