SCHEMBL290061

SCHEMBL290061

COCCCn1c(=O)oc2ccc(-c3ccc(CC(C#N)NC(=O)C4CCOCC4)cc3)cc21

nearest known ligand 0.73

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTSC P53634 20/20 0.73
KCNH2 Q12809 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL288984 0.95 CTSC (0.72) CTSCKCNH2
SCHEMBL289755 0.86 CTSC (0.69) CTSCKCNH2
SCHEMBL2892497 0.86 CTSC (0.64) CTSCKCNH2
SCHEMBL2892500 0.86 CTSC (0.64) CTSCKCNH2
SCHEMBL3687602 0.85 CTSC (0.72) CTSCKCNH2
SCHEMBL3687606 0.85 CTSC (0.72) CTSCKCNH2
SCHEMBL15084032 0.85 CTSC (1.00) CTSC
SCHEMBL2885392 0.84 CTSC (0.62) CTSCKCNH2
SCHEMBL7858106 0.83 CTSC (0.64) CTSCKCNH2
SCHEMBL15083918 0.83 CTSC (0.64) CTSCKCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2427445-A1 SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 AstraZeneca AB (SE) 2012-03-14 EP claimed
EP-2427445-A1 SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 AstraZeneca AB (SE) 2012-03-14 EP disclosed