Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.43 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 5/20 | 0.42 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.42 |
| ▸ | FOS | P01100 | 1/20 | 0.41 |
| ▸ | JUN | P05412 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181224 | 0.91 | KDM4E (0.46) | MEN1MAPTKMT2AKDM4EHSP90AA1 | |
| SCHEMBL20176200 | 0.87 | KDM4E (0.50) | MEN1MAPTKMT2AKDM4EHSP90AA1 | |
| SCHEMBL288852 | 0.86 | KDM4E (0.59) | JAK2JAK3MEN1MAPTKMT2A | |
| SCHEMBL290560 | 0.84 | BCL2L1 (0.40) | MAPTALDH1A1LMNA | |
| SCHEMBL300086 | 0.79 | KDM4E (0.49) | MEN1MAPTKMT2AKDM4EHSP90AA1 | |
| SCHEMBL289614 | 0.79 | KDM4E (0.64) | JAK2JAK3MEN1MAPTKMT2A | |
| SCHEMBL290424 | 0.79 | CDC7 (0.52) | JAK2JAK3MAPTKDM4EALDH1A1 | |
| SCHEMBL5641718 | 0.78 | CDC7 (0.68) | MEN1MAPTKMT2AKDM4EHSP90AA1 | |
| SCHEMBL299676 | 0.77 | KDM4E (0.72) | MEN1MAPTKMT2AKDM4EHSP90AA1 | |
| SCHEMBL289679 | 0.75 | KDM4E (0.53) | MEN1MAPTKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |