Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | CRHBP | P24387 | 1/20 | 0.52 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 5/20 | 0.45 |
| ▸ | DBF4 | Q9UBU7 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290132 | 0.84 | KDM4E (1.00) | KDM4EALDH1A1KMT2AMAPTGAA | |
| SCHEMBL5641718 | 0.81 | CDC7 (0.68) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL300086 | 0.81 | KDM4E (0.49) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL17291419 | 0.81 | CDC7 (0.70) | KDM4EKMT2AMEN1MAPTHSP90AA1 | |
| SCHEMBL8341363 | 0.81 | MAPT (0.78) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3666287 | 0.80 | KDM4E (0.53) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL5640705 | 0.79 | CDC7 (0.56) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL20181224 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL290062 | 0.77 | JAK2 (0.46) | KDM4EALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL24303679 | 0.77 | MAPT (0.62) | KDM4EKMT2AMEN1MAPTHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |