Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.65 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29674761 | 1.00 | ROCK2 (0.65) | ROCK2ROCK1LCKAURKACCNA2 | |
| SCHEMBL28777047 | 0.93 | ROCK2 (0.65) | ROCK2ROCK1LCKAURKACCNA2 | |
| SCHEMBL29674683 | 0.93 | ROCK2 (0.65) | ROCK2ROCK1LCKAURKACCNA2 | |
| SCHEMBL29674616 | 0.86 | ROCK2 (0.66) | ROCK2ROCK1AURKACCNA2CDK2 | |
| SCHEMBL28776995 | 0.86 | ROCK2 (0.66) | ROCK2ROCK1AURKACCNA2CDK2 | |
| SCHEMBL29674653 | 0.82 | ROCK2 (0.66) | ROCK2ROCK1AURKACCNA2CDK2 | |
| SCHEMBL28776986 | 0.82 | ROCK2 (0.66) | ROCK2ROCK1AURKACCNA2CDK2 | |
| SCHEMBL16637772 | 0.81 | ROCK2 (0.69) | ROCK2ROCK1AURKACCNA2CDK2 | |
| SCHEMBL16637773 | 0.79 | ROCK2 (1.00) | ROCK2ROCK1 | |
| SCHEMBL29007155 | 0.78 | LCK (0.45) | ROCK2ROCK1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114573566-B | Selective ROCK2 kinase inhibitors | 杭州邦顺制药有限公司 | 2023-05-30 | — | — | CN | disclosed |