Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.61 |
| ▸ | CA2 | P00918 | 3/20 | 0.61 |
| ▸ | CA4 | P22748 | 3/20 | 0.61 |
| ▸ | CA12 | O43570 | 2/20 | 0.61 |
| ▸ | CA3 | P07451 | 2/20 | 0.61 |
| ▸ | CA9 | Q16790 | 2/20 | 0.61 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.60 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 3/20 | 0.56 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | TYR | P14679 | 1/20 | 0.56 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.56 |
| ▸ | CA6 | P23280 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL28009537 | 1.00 | CA1 (0.61) | CA1CA2CA4CA12CA3 | |
| Maleic Acid SCHEMBL19128787 | 1.00 | CA1 (0.61) | CA1CA2CA4CA12CA3 | |
| Maleic Acid SCHEMBL21816858 | 1.00 | CA1 (0.61) | CA1CA2CA4CA12CA3 | |
| Fumaric Acid SCHEMBL523843 | 1.00 | CA1 (0.61) | CA1CA2CA4CA12CA3 | |
| Fumaric Acid SCHEMBL10892029 | 1.00 | CA1 (0.61) | CA1CA2CA4CA12CA3 | |
| Fumaric Acid SCHEMBL28149326 | 0.95 | ALDH1A1 (0.56) | CA1CA2CA4CA12CA3 | |
| Maleic Acid SCHEMBL27635288 | 0.95 | ALDH1A1 (0.56) | CA1CA2CA4CA12CA3 | |
| Phenol SCHEMBL28258965 | 0.89 | MAPT (0.50) | CA1CA2CA4CA12CA3 | |
| Fumaric Acid SCHEMBL30327066 | 0.88 | MAPT (0.73) | CA1CA2CA4CA12CA3 | |
| Maleic Acid SCHEMBL11213277 | 0.88 | MAPT (0.73) | CA1CA2CA4CA12CA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116178292-A | Fluoroalkyl and aza group substituted nucleoside analogue precursor, its synthesis method and medical use | 吴卫东 | 2023-05-30 | — | — | CN | claimed |
| CN-114605472-A | TAF oxidation degradation impurity, preparation method and application | 石家庄龙泽制药股份有限公司 | 2022-06-10 | — | — | CN | claimed |
| CN-116178292-A | Fluoroalkyl and aza group substituted nucleoside analogue precursor, its synthesis method and medical use | 吴卫东 | 2023-05-30 | — | — | CN | disclosed |
| CN-115524408-A | Method for detecting related substances in emtricitabine-propofol-tenofovir tablet compound preparation | 成都倍特药业股份有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-112782311-B | HPLC (high performance liquid chromatography) determination method for L-isopropyl alanine in propane phenol fumarate tenofovir | 南京百泽医药科技有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-112782311-B | HPLC (high performance liquid chromatography) determination method for L-isopropyl alanine in propane phenol fumarate tenofovir | 南京百泽医药科技有限公司 | 2022-12-27 | — | — | CN | disclosed |
| CN-115260236-A | High-optical-purity intermediate for synthesizing propane fumarate tenofovir and preparation method thereof | 四川科伦药业股份有限公司 | 2022-11-01 | — | — | CN | disclosed |
| CN-114295767-B | Medicine impurity detection method based on propane fumarate tenofovir disoproxil tablets | 湖南明瑞制药有限公司 | 2022-06-03 | — | — | CN | disclosed |