SCHEMBL29008446

SCHEMBL29008446

CCCc1c[nH]c(-c2c[nH]nc2Cc2ccco2)n1

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.33
KDM4E B2RXH2 1/20 0.33
RAB9A P51151 2/20 0.32
CDC25A P30304 1/20 0.32
NPC1 O15118 1/20 0.32
MAPT P10636 1/20 0.31
TSHR P16473 1/20 0.31
HPGD P15428 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29008496 0.83 HPGD (0.33) ALDH1A1KDM4ETSHRHPGD
SCHEMBL29008448 0.81
SCHEMBL29008449 0.80 CDK5 (0.31) MAPT
SCHEMBL29008483 0.79
SCHEMBL29008474 0.79 HCAR2 (0.37)
SCHEMBL29008463 0.78
SCHEMBL29008499 0.78 L3MBTL1 (0.39) ALDH1A1HPGD
SCHEMBL29008471 0.78 TSHR (0.37) ALDH1A1RAB9ANPC1TSHR
SCHEMBL29008461 0.77
SCHEMBL29008485 0.76 ALDH1A1 (0.33) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116194537-A Combination therapy with adenosine receptor antagonists 泰昂治疗公司 2023-05-30 CN disclosed