Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.38 |
| ▸ | FLT1 | P17948 | 4/20 | 0.38 |
| ▸ | ITK | Q08881 | 2/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | CBFB | Q13951 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.37 |
| ▸ | SCD | O00767 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30382244 | 1.00 | PDPK1 (0.42) | PDPK1CHEK1FLT3FGFR1FLT1 | |
| SCHEMBL29009489 | 0.82 | PDPK1 (0.50) | PDPK1CHEK1FLT3FGFR1FLT1 | |
| SCHEMBL30382285 | 0.82 | PDPK1 (0.63) | PDPK1FLT3FGFR1FLT1CBFB | |
| SCHEMBL29009502 | 0.82 | PDPK1 (0.63) | PDPK1FLT3FGFR1FLT1CBFB | |
| SCHEMBL29009493 | 0.81 | FGFR1 (0.59) | PDPK1CHEK1FLT3FGFR1FLT1 | |
| SCHEMBL29009505 | 0.79 | MAPK1 (0.59) | PDPK1CHEK1FLT3FGFR1ITK | |
| SCHEMBL29009504 | 0.79 | PDPK1 (0.41) | PDPK1FGFR1FLT1 | |
| SCHEMBL29009490 | 0.77 | CHEK1 (0.45) | PDPK1CHEK1FLT3FGFR1FLT1 | |
| SCHEMBL30382584 | 0.77 | CHEK1 (0.45) | PDPK1CHEK1FLT3FGFR1FLT1 | |
| SCHEMBL31006258 | 0.75 | ITK (0.46) | PDPK1CHEK1FLT3FGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116217551-A | Substituted indazole or azaindazole compounds and application thereof | 河南中医药大学 | 2023-06-06 | — | — | CN | claimed |
| CN-116217551-A | Substituted indazole or azaindazole compounds and application thereof | 河南中医药大学 | 2023-06-06 | — | — | CN | disclosed |