Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 4/20 | 0.49 |
| ▸ | DBF4 | Q9UBU7 | 4/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289614 | 0.88 | KDM4E (0.64) | KDM4EALDH1A1LMNACDC7DBF4 | |
| SCHEMBL290000 | 0.85 | SMN1; SMN2 (0.52) | KDM4EALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL290390 | 0.84 | CDC7 (0.61) | KDM4EALDH1A1LMNACDC7DBF4 | |
| SCHEMBL288852 | 0.84 | KDM4E (0.59) | KDM4EALDH1A1LMNACDC7DBF4 | |
| SCHEMBL290020 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1LMNACDC7DBF4 | |
| SCHEMBL290184 | 0.82 | CDC7 (0.56) | KDM4EALDH1A1LMNACDC7DBF4 | |
| SCHEMBL289540 | 0.82 | KDM4E (0.54) | KDM4EALDH1A1LMNACDC7DBF4 | |
| SCHEMBL290167 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1LMNACDC7DBF4 | |
| SCHEMBL290427 | 0.80 | CDC7 (0.57) | KDM4EALDH1A1LMNACDC7DBF4 | |
| SCHEMBL289397 | 0.78 | LMNA (0.54) | KDM4EALDH1A1LMNACDC7DBF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |