Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289881 | 0.86 | SMN1; SMN2 (0.61) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL290095 | 0.85 | KDM4E (0.53) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL289595 | 0.81 | SMN1; SMN2 (0.68) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL290238 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL290016 | 0.81 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL290152 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL290470 | 0.80 | SMN1; SMN2 (0.64) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL290011 | 0.78 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL289925 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2KDM4EKMT2ARAB9AGAA | |
| SCHEMBL3828069 | 0.75 | LMNA (0.51) | SMN1; SMN2KDM4EKMT2AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |