Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25250445 | 0.93 | HDAC4 (0.38) | HDAC4TRPV4 | |
| SCHEMBL1671064 | 0.75 | PDE10A (0.47) | HDAC4TRPV4 | |
| SCHEMBL2902738 | 0.74 | TRPV4 (0.31) | TRPV4 | |
| SCHEMBL15515636 | 0.74 | TRPV4 (0.31) | TRPV4 | |
| Methane SCHEMBL28258530 | 0.73 | PDE10A (0.45) | HDAC4TRPV4 | |
| Hydrochloric Acid SCHEMBL4574425 | 0.73 | PDE10A (0.45) | HDAC4TRPV4 | |
| Ethane SCHEMBL27894198 | 0.72 | PDE10A (0.44) | HDAC4 | |
| SCHEMBL19924588 | 0.72 | ALDH1A1 (0.42) | — | |
| SCHEMBL6717510 | 0.72 | BCHE (0.31) | — | |
| SCHEMBL3483213 | 0.72 | CYP1A2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2160187-B1 | SPIROINDALONES | MERCK SHARP & DOHME (US) | 2013-05-22 | — | — | EP | claimed |
| US-8309544-B2 | Spiroindalones | MERCK SHARP & DOHME CORP. (US) | 2012-11-13 | — | — | US | claimed |
| US-20100137297-A1 | SPIROINDALONES | MERCK SHARP & DOHME LLC | 2010-06-03 | — | — | US | claimed |
| CN-101678011-A | Spiro-indolinone compounds | MERCK & CO INC | 2010-03-24 | — | — | CN | claimed |
| EP-2160187-A1 | SPIROINDALONES | Merck Sharp & Dohme Corp. (US) | 2010-03-10 | — | — | EP | claimed |
| WO-2008144266-A1 | SPIROINDALONES | MERCK & CO., INC. (US) | 2008-11-27 | — | — | WO | claimed |
| EP-2160187-B1 | SPIROINDALONES | MERCK SHARP & DOHME (US) | 2013-05-22 | — | — | EP | disclosed |
| US-8309544-B2 | Spiroindalones | MERCK SHARP & DOHME CORP. (US) | 2012-11-13 | — | — | US | disclosed |
| CN-101678011-B | Spiro-indolinone compounds | MERCK SHARP & DOHME | 2012-07-18 | — | — | CN | disclosed |
| US-20100137297-A1 | SPIROINDALONES | MERCK SHARP & DOHME LLC | 2010-06-03 | — | — | US | disclosed |
| CN-101678011-A | Spiro-indolinone compounds | MERCK & CO INC | 2010-03-24 | — | — | CN | disclosed |
| EP-2160187-A1 | SPIROINDALONES | Merck Sharp & Dohme Corp. (US) | 2010-03-10 | — | — | EP | disclosed |
| WO-2008144266-A1 | SPIROINDALONES | MERCK & CO., INC. (US) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137297-A1 | SPIROINDALONES | HIF1AN, HIF1A, EGLN2 | HDAC4 324/4885TRPV4 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.