Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29013134 | 0.93 | SOS1 (0.46) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL25335301 | 0.90 | NR3C1 (0.43) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL25332284 | 0.85 | NR3C1 (0.41) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL29013157 | 0.85 | DDB1 (0.42) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL29013153 | 0.83 | DDB1 (0.43) | ALDH1A1KDM4ESMN1; SMN2GAATSHR | |
| SCHEMBL30501235 | 0.83 | SOS1 (0.46) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL25935489 | 0.83 | SOS1 (0.46) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL30135978 | 0.82 | DDB1 (0.39) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL23134537 | 0.81 | SOS1 (0.45) | NR3C1PGRSLC6A4KCNH2PDE3B | |
| SCHEMBL31213547 | 0.81 | SOS1 (0.46) | NR3C1PGRSLC6A4KCNH2PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |