Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.39 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.38 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | NQO1 | P15559 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8787765 | 0.84 | MAPK1 (0.48) | BRD4PIK3CAPRKDCPIK3CD | |
| SCHEMBL7081757 | 0.76 | APP (0.41) | APPMAPKAPK2HSD17B1HSD17B2BRD4 | |
| SCHEMBL3398344 | 0.74 | KDM4E (0.51) | APP | |
| SCHEMBL30556736 | 0.74 | METAP2 (0.38) | BRD4TNIK | |
| SCHEMBL31619990 | 0.74 | METAP2 (0.38) | BRD4TNIK | |
| SCHEMBL19133572 | 0.74 | APP (0.57) | APPHSD17B1HSD17B2BRD4CREBBP | |
| SCHEMBL10213947 | 0.72 | KDR (0.51) | APPMAPKAPK2PIK3CAPRKDCPIK3CD | |
| SCHEMBL17145024 | 0.72 | BCHE (0.41) | — | |
| SCHEMBL12854022 | 0.72 | APP (0.55) | APPHSD17B1HSD17B2BRD4CREBBP | |
| SCHEMBL28284665 | 0.71 | MGAM (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116234803-A | Combinations of estrogen receptor degrading agents and cyclin-dependent kinase inhibitors for the treatment of cancer | 冰洲石生物科技公司 | 2023-06-06 | — | — | CN | disclosed |