Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 19/20 | 0.80 |
| ▸ | DHFR | P00374 | 1/20 | 0.80 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.80 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9488317 | 0.99 | DHODH (0.81) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL4266 | 0.90 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23832490 | 0.89 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL49400 | 0.89 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL29688590 | 0.89 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL29355220 | 0.89 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL6037352 | 0.89 | DHODH (0.88) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23113785 | 0.88 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL21378179 | 0.88 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23828306 | 0.88 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116077665-A | Compounds for the treatment of ophthalmic diseases and disorders | 奇奥拉制药股份有限公司 | 2023-05-09 | — | — | CN | disclosed |