Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 19/20 | 0.81 |
| ▸ | DHFR | P00374 | 1/20 | 0.81 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.81 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29014188 | 0.99 | DHODH (0.80) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23832490 | 0.90 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL49400 | 0.90 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL29355220 | 0.90 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL29688590 | 0.90 | DHODH (1.00) | DHODHDHFRALKBH5PDE10A | |
| SCHEMBL6037352 | 0.90 | DHODH (0.88) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL4266 | 0.89 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23113785 | 0.89 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL21378179 | 0.89 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A | |
| Brequinar SCHEMBL23828306 | 0.89 | DHODH (0.98) | DHODHDHFRALKBH5PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114288294-A | Compounds and methods for treating or preventing hematologic cancers | 布罗德研究所股份有限公司 | 2022-04-08 | — | — | CN | claimed |
| CN-117915938-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase in combination with anti-CD 47-sirpa therapeutic agents | 俄亥俄州国家创新基金会 | 2024-04-19 | — | — | CN | disclosed |
| CN-116457468-A | Production of high-yielding recombinant chinese hamster ovary cell lines for therapeutic protein production | 赛诺菲 | 2023-07-18 | — | — | CN | disclosed |
| CN-115361948-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase | 俄亥俄州国家创新基金会 | 2022-11-18 | — | — | CN | disclosed |
| CN-115335052-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase in combination with anti-CD 38 therapeutics | 俄亥俄州国家创新基金会 | 2022-11-11 | — | — | CN | disclosed |
| CN-112672744-B | Methods and compositions for inhibiting dihydroorotate dehydrogenase | 俄亥俄州国家创新基金会 | 2022-10-14 | — | — | CN | disclosed |
| CN-114288294-A | Compounds and methods for treating or preventing hematologic cancers | 布罗德研究所股份有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-114288294-A | Compounds and methods for treating or preventing hematologic cancers | 布罗德研究所股份有限公司 | 2022-04-08 | — | — | CN | disclosed |
| CN-113811615-A | Novel cell lines comprising a selection marker and their use for protein production | 赛诺菲 | 2021-12-17 | — | — | CN | disclosed |
| CN-107109435-B | Novel selectable markers for cell transfection and protein production | 赛诺菲 | 2021-10-22 | — | — | CN | disclosed |
| CN-112672744-A | Methods and compositions for inhibiting dihydroorotate dehydrogenase | 俄亥俄州国家创新基金会 | 2021-04-16 | — | — | CN | disclosed |
| EP-0339485-B1 | 4-QUINOLINE CARBOXYLIC ACID DERIVATIVES USEFUL AS IMMUNOSUPPRESSIVE AGENTS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-03-31 | — | — | EP | disclosed |
| EP-0339484-B1 | 4-QUINOLINE CARBOXYLIC ACID DERIVATIVES USEFUL FOR TREATING SKIN AND MUCO-EPITHELIAL DISEASES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-01-20 | — | — | EP | disclosed |
| US-5084462-A | Immunomodulators and antiinflammatory agents for autoimmune diseases and organ rejection | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1992-01-28 | — | — | US | disclosed |
| US-4968701-A | AUTOIMMUNE DISEASES, ORGAN TRANSPLANT REJECTION, MULTIPLE SCLEROSIS, RHEUMATOID ARTHRITIS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-11-06 | — | — | US | disclosed |
| EP-0362578-A1 | Treatment of cancer in mammals by concurrent administration of 4-quinoline carboxylic acid derivatives and interleukin-2 | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1990-04-11 | — | — | EP | disclosed |
| EP-0339484-A1 | 4-Quinoline carboxylic acid derivatives useful for treating skin and muco-epithelial diseases | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1989-11-02 | — | — | EP | disclosed |
| EP-0339485-A1 | 4-Quinoline carboxylic acid derivatives useful as immunosuppressive agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1989-11-02 | — | — | EP | disclosed |