SCHEMBL29015152

SCHEMBL29015152

ON=C1Cc2ccc(F)cc2C1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA6 P23280 2/20 0.37
CA3 P07451 1/20 0.37
CA5A P35218 1/20 0.37
CA9 Q16790 1/20 0.37
CA14 Q9ULX7 1/20 0.37
CA5B Q9Y2D0 1/20 0.37
CA1 P00915 2/20 0.35
CA2 P00918 2/20 0.35
PDE3A Q14432 1/20 0.35
BRAF P15056 1/20 0.35
CA4 P22748 1/20 0.33
DPP9 Q86TI2 3/20 0.32
DPP4 P27487 2/20 0.32
DPP8 Q6V1X1 2/20 0.32
DPP7 Q9UHL4 2/20 0.32
NOTUM Q6P988 1/20 0.32
PARP1 P09874 2/20 0.31
ADRA2A P08913 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5378351 0.86 NPC1 (0.33) CA6CA3CA5ACA9CA14
SCHEMBL5378345 0.86 NPC1 (0.33) CA6CA3CA5ACA9CA14
Ammonia Solution, Strong SCHEMBL2208350 0.77
Water SCHEMBL28759228 0.77
SCHEMBL12693416 0.75 METAP1 (0.39) BRAFNOTUMPARP1ADRA2AACHE
SCHEMBL30043019 0.73 HSD17B1 (0.48) ESR1ESR2
SCHEMBL29187375 0.73 HSD17B1 (0.48) ESR1ESR2
SCHEMBL6907006 0.73 CA1 (0.44) CA6CA1CA2CA4PARP1
SCHEMBL29392481 0.72 CYP1A2 (0.43) CYP1A2
SCHEMBL5190200 0.72 CYP1A2 (0.43) CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116096712-A Novel compounds NRG治疗有限公司 2023-05-09 CN disclosed