Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 4/20 | 0.68 |
| ▸ | APP | P05067 | 4/20 | 0.68 |
| ▸ | RAB9A | P51151 | 10/20 | 0.66 |
| ▸ | NPC1 | O15118 | 9/20 | 0.66 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MITF | O75030 | 1/20 | 0.51 |
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | KDM5C | P41229 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2906109 | 0.98 | ALDH1A3 (0.70) | ALDH1A3APPRAB9ANPC1PAX8 | |
| SCHEMBL13198289 | 0.90 | ALDH1A3 (0.75) | ALDH1A3APPRAB9ANPC1PAX8 | |
| SCHEMBL13325701 | 0.86 | ALDH1A3 (0.74) | ALDH1A3APPRAB9ANPC1PAX8 | |
| Bromide SCHEMBL3300229 | 0.85 | ALDH1A3 (0.68) | ALDH1A3APPRAB9ANPC1PAX8 | |
| SCHEMBL2817276 | 0.84 | ALDH1A3 (0.70) | ALDH1A3APPRAB9ANPC1PAX8 | |
| SCHEMBL2899627 | 0.84 | ALDH1A3 (0.70) | ALDH1A3APPRAB9ANPC1PAX8 | |
| SCHEMBL10527726 | 0.84 | ALDH1A3 (0.70) | ALDH1A3APPRAB9ANPC1PAX8 | |
| SCHEMBL28338009 | 0.83 | ALDH1A3 (0.81) | ALDH1A3APPRAB9ANPC1KDM4E | |
| Bromide SCHEMBL1691457 | 0.82 | NPC1 (0.75) | ALDH1A3APPRAB9ANPC1PAX8 | |
| SCHEMBL2127814 | 0.81 | NPC1 (0.57) | ALDH1A3APPRAB9ANPC1PAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216994-A1 | USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME | NIHON MEDI-PHYSICS CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| EP-2216052-A1 | USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME | Nihon Medi-Physics Co., Ltd. (JP) | 2010-08-11 | — | — | EP | disclosed |
| US-20090252680-A1 | NOVEL COMPOUND WITH AFFINITY FOR AMYLOID | NIHON- MEDI-PHYSICS CO., LTD (JP) | 2009-10-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216994-A1 | USE OF NOVEL COMPOUND HAVING AFFINITY FOR AMYLOID, AND PROCESS FOR PRODUCTION OF THE SAME | APBA1, APP, S100A4 | ALDH1A3 2637/4885APP 2/4885RAB9A 2882/4885 |
| US-20090252680-A1 | NOVEL COMPOUND WITH AFFINITY FOR AMYLOID | APBA1, APP, SLC7A1 | ALDH1A3 3051/4885APP 2/4885RAB9A 1766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.