Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28791102 | 0.88 | ATM (0.41) | HTR2AMEN1KMT2AS1PR1CNR2 | |
| SCHEMBL27894669 | 0.87 | POLB (0.44) | MEN1KMT2AS1PR1CNR2 | |
| SCHEMBL2915152 | 0.87 | PSEN1 (0.45) | HTR2AS1PR1S1PR5CNR2KDM4E | |
| SCHEMBL2903465 | 0.86 | CHRM4 (0.42) | HTR2ACNR2 | |
| SCHEMBL27848935 | 0.83 | PSEN1 (0.40) | LMNAHTR2AMEN1KMT2AS1PR1 | |
| SCHEMBL2903682 | 0.83 | PDE2A (0.41) | S1PR1CNR2 | |
| SCHEMBL2903669 | 0.83 | PSEN1 (0.39) | S1PR1KDM4E | |
| SCHEMBL27848836 | 0.82 | L3MBTL1 (0.48) | CNR2KDM4E | |
| SCHEMBL27848808 | 0.81 | L3MBTL1 (0.44) | MEN1KMT2AS1PR1KDM4E | |
| SCHEMBL10129797 | 0.80 | PSEN1 (0.42) | LMNAHTR2AMEN1KMT2AS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2212287-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF y-SECRETASE | Janssen Pharmaceutica, N.V. (BE) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009052126-A1 | PIPERIDINYL AND PIPERAZINYL MODULATORS OF γ-SECRETASE | JANSSEN PHARMACEUTICA, N.V. (BE) | 2009-04-23 | — | — | WO | disclosed |