Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2915152 | 0.95 | PSEN1 (0.45) | ATML3MBTL1CNR2CYP2D6DRD2 | |
| SCHEMBL2903465 | 0.92 | CHRM4 (0.42) | ATML3MBTL1CNR2DRD2DRD4 | |
| SCHEMBL27894669 | 0.92 | POLB (0.44) | ATML3MBTL1CNR2S1PR1S1PR3 | |
| SCHEMBL27848935 | 0.91 | PSEN1 (0.40) | ATML3MBTL1CYP2D6DRD2DRD4 | |
| SCHEMBL27848836 | 0.91 | L3MBTL1 (0.48) | ATML3MBTL1CNR2KDM4EALDH1A1 | |
| SCHEMBL2903682 | 0.90 | PDE2A (0.41) | ATML3MBTL1CNR2DRD2DRD4 | |
| SCHEMBL2903669 | 0.90 | PSEN1 (0.39) | DRD2DRD4KDM4EPSEN1PSEN2 | |
| SCHEMBL2901715 | 0.88 | LMNA (0.41) | CNR2KDM4ES1PR1MEN1NPC1 | |
| SCHEMBL27848822 | 0.88 | PSEN1 (0.40) | KDM4EPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2922993 | 0.85 | PSEN1 (0.47) | L3MBTL1DRD2DRD4PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101903347-B | Piperidinyl and piperazinyl modulators of gamma-secretase | JANSSEN PHARMACEUTICA NV | 2013-03-27 | — | — | CN | disclosed |
| CN-101903347-A | Piperidinyl and piperazinyl modulators of gamma-secretase | JANSSEN PHARMACEUTICA NV | 2010-12-01 | — | — | CN | disclosed |