Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.49 |
| ▸ | RAB9A | P51151 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290238 | 0.76 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1BCL2L1 | |
| SCHEMBL290196 | 0.75 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2BCL2L1RPS6KB2 | |
| SCHEMBL289628 | 0.74 | SMN1; SMN2 (0.63) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| SCHEMBL6412727 | 0.73 | BCL2L1 (0.64) | RAB9AALDH1A1BCL2L1HPGDPOLB | |
| SCHEMBL289881 | 0.72 | SMN1; SMN2 (0.61) | NPC1RAB9ASMN1; SMN2ALDH1A1BCL2L1 | |
| SCHEMBL290152 | 0.69 | SMN1; SMN2 (0.53) | NPC1RAB9ASMN1; SMN2ALDH1A1BCL2L1 | |
| SCHEMBL290016 | 0.69 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2ALDH1A1BCL2L1 | |
| SCHEMBL289595 | 0.69 | SMN1; SMN2 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4919866 | 0.69 | NPC1 (0.75) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM | |
| Hydrochloric Acid SCHEMBL8555706 | 0.68 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |