Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 10/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | NPC1 | O15118 | 8/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | HPGD | P15428 | 6/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | DHODH | Q02127 | 1/20 | 0.53 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL288852 | 0.80 | KDM4E (0.59) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL290528 | 0.80 | NPC1 (0.46) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL298147 | 0.78 | SMN1; SMN2 (0.75) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL289614 | 0.78 | KDM4E (0.64) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL3584407 | 0.76 | SMN1; SMN2 (0.80) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL289683 | 0.76 | SMN1; SMN2 (1.00) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL289540 | 0.74 | KDM4E (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL290195 | 0.74 | NPC1 (0.49) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL290020 | 0.74 | KDM4E (0.56) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL290390 | 0.74 | CDC7 (0.61) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |