Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | HSD17B1 | P14061 | 13/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 13/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL290528 | 0.87 | NPC1 (0.46) | SMN1; SMN2NPC1LMNACASP3RAB9A | |
| SCHEMBL290238 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ABCL2L1KDM4E | |
| SCHEMBL290195 | 0.75 | NPC1 (0.49) | SMN1; SMN2NPC1LMNARAB9ABCL2L1 | |
| SCHEMBL6412727 | 0.75 | BCL2L1 (0.64) | RAB9AHSD17B1HSD17B2BCL2L1RPS6KB2 | |
| SCHEMBL289881 | 0.74 | SMN1; SMN2 (0.61) | SMN1; SMN2NPC1RAB9ABCL2L1KDM4E | |
| SCHEMBL290152 | 0.71 | SMN1; SMN2 (0.53) | SMN1; SMN2NPC1LMNARAB9ABCL2L1 | |
| SCHEMBL290016 | 0.70 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9ABCL2L1KDM4E | |
| SCHEMBL289595 | 0.70 | SMN1; SMN2 (0.68) | SMN1; SMN2NPC1LMNARAB9AKDM4E | |
| SCHEMBL290470 | 0.68 | SMN1; SMN2 (0.64) | SMN1; SMN2NPC1LMNARAB9AHSD17B1 | |
| SCHEMBL290000 | 0.68 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9ABCL2L1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427447-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | Pike Pharma GmbH (CH) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128163-A2 | SMALL MOLECULE INHIBITORS OF INFLUENZA A AND B VIRUS AND RESPIRATORY SYNCYTIAL VIRUS REPLICATION | PIKE PHARMA GMBH (CH) | 2010-11-11 | — | — | WO | disclosed |