Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29020164 | 0.85 | CHEK1 (0.57) | CHEK1STING1CLK2LRRK2MAP4K4 | |
| SCHEMBL29961571 | 0.85 | CHEK1 (0.57) | CHEK1STING1CLK2LRRK2MAP4K4 | |
| SCHEMBL29961693 | 0.83 | CHEK1 (0.53) | CHEK1STING1MAP4K4CCNCCDK8 | |
| SCHEMBL29020112 | 0.83 | CHEK1 (0.53) | CHEK1STING1MAP4K4CCNCCDK8 | |
| SCHEMBL29020185 | 0.82 | ROCK2 (0.47) | CLK2LRRK2EGFR | |
| SCHEMBL29020125 | 0.79 | CHEK1 (0.53) | CHEK1MAP4K4CCNCCDK8PIM1 | |
| SCHEMBL29020180 | 0.78 | CHEK1 (0.50) | CHEK1MAP4K4CCNCCDK8PIM1 | |
| SCHEMBL29961338 | 0.78 | CHEK1 (0.50) | CHEK1MAP4K4CCNCCDK8PIM1 | |
| SCHEMBL29961343 | 0.78 | CLK2 (0.56) | CHEK1CLK2LRRK2MAP4K4CCNC | |
| SCHEMBL31174355 | 0.78 | CHEK1 (0.47) | CHEK1STING1CLK2LRRK2MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115093400-B | AhR inhibitor, application and preparation method thereof | 北京华森英诺生物科技有限公司 | 2023-09-05 | — | — | CN | disclosed |
| CN-115093400-A | AhR inhibitor and application and preparation method thereof | 重庆华森制药股份有限公司 | 2022-09-23 | — | — | CN | disclosed |