⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL492384 | 1.00 | — | — | |
| SCHEMBL91528 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL8936724 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL3947086 | 0.98 | — | — | |
| Dimethylamine SCHEMBL11532400 | 0.94 | CHRM1 (0.42) | — | |
| SCHEMBL92502 | 0.86 | — | — | |
| SCHEMBL3012906 | 0.86 | — | — | |
| SCHEMBL13665710 | 0.86 | — | — | |
| SCHEMBL78025 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL4435602 | 0.85 | CHRNB2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5578728-A | Process for the preparation of a benzo(a)quinolizione derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | claimed |
| JP-7188229-A | — | — | None | — | — | JP | disclosed |
| US-20240294498-A1 | FACTOR XIIA INHIBITORS | LUNAC THERAPEUTICS LTD (GB) | 2024-09-05 | — | — | US | disclosed |
| US-20230010358-A1 | Spiro-Sulfonamide Derivatives As Inhibitors Of Myeloid Cell Leukemia-1 (MCL-1) Protein | PRELUDE THERAPEUTICS, INCORPORATED | 2023-01-12 | — | — | US | disclosed |
| US-11254686-B1 | Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor | CORVUS PHARMACEUTICALS, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| US-11130769-B2 | Spiro-sulfonamide derivatives as inhibitors of myeloid cell leukemia-1 (MCL-1) protein | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2021-09-28 | — | — | US | disclosed |
| EP-3877390-A1 | SPIRO-SULFONAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN | Prelude Therapeutics, Incorporated (US) | 2021-09-15 | — | — | EP | disclosed |
| CN-113166173-A | Spiro-sulfonamide derivatives as inhibitors of myeloid leukemia 1(MCL-1) protein | 普莱鲁德疗法有限公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-111629728-A | Compounds and methods for modulating adenosine A2B receptor and adenosine A2A receptor | 科尔沃斯制药股份有限公司 | 2020-09-04 | — | — | CN | disclosed |
| EP-3675856-A1 | COMPOUNDS AND METHODS FOR MODULATING ADENOSINE A2B RECEPTOR AND ADENOSINE A2A RECEPTOR | Corvus Pharmaceuticals, Inc. (US) | 2020-07-08 | — | — | EP | disclosed |
| US-5578728-A | Process for the preparation of a benzo(a)quinolizione derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5578728-A | Process for the preparation of a benzo(a)quinolizione derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5561233-A | Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-10-01 | — | — | US | disclosed |
| US-5561233-A | Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-10-01 | — | — | US | disclosed |
| EP-0496274-B1 | Tricyclic pyridone derivative | HOFFMANN LA ROCHE (CH) | 1996-07-03 | — | — | EP | disclosed |
| JP-H07188229-A | PREPARATION OF BENZO(A)QUINOLIZINONE DERIVATIVE | F HOFFMANN LA ROCHE AG | 1995-07-25 | — | — | JP | disclosed |
| EP-0650966-A1 | Process for the preparation of a benzo(a)quinolizinone derivative | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-03 | — | — | EP | disclosed |
| US-5326769-A | Treatment of sleep disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-07-05 | — | — | US | disclosed |
| US-5281711-A | (S)-1-[10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quino-lizin-1-yl)carbonyl]-3-ethoxypyrrolidine | HOFFMANN-LA ROCHE INC. (US) | 1994-01-25 | — | — | US | disclosed |
| EP-0496274-A1 | Tricyclic pyridone derivative | F. Hoffmann-La Roche AG (CH) | 1992-07-29 | — | — | EP | disclosed |