⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL91528 | 1.00 | — | — | |
| SCHEMBL2902167 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL8936724 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL3947086 | 0.98 | — | — | |
| Dimethylamine SCHEMBL11532400 | 0.94 | CHRM1 (0.42) | — | |
| SCHEMBL92502 | 0.86 | — | — | |
| SCHEMBL3012906 | 0.86 | — | — | |
| SCHEMBL13665710 | 0.86 | — | — | |
| SCHEMBL78025 | 0.85 | — | — | |
| Hydrochloric Acid SCHEMBL4435602 | 0.85 | CHRNB2 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 137 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103118540-B | Pesticide containing 2, 5-diketopiperazine derivative as active ingredient | Rural Development Office (KR) | 2016-02-17 | — | — | CN | claimed |
| CN-103118540-A | Pesticide containing 2, 5-diketopiperazine derivative as active ingredient | REPUBLIC KOREA MAN RURAL DEV | 2013-05-22 | — | — | CN | claimed |
| EP-1465864-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | Warner-Lambert Company LLC (US) | 2004-10-13 | — | — | EP | claimed |
| WO-2003045912-A1 | INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE | WARNER-LAMBERT COMPANY LLC (US) | 2003-06-05 | — | — | WO | claimed |
| US-5578728-A | Process for the preparation of a benzo(a)quinolizione derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | claimed |
| JP-7188229-A | — | — | None | — | — | JP | disclosed |
| US-20260109696-A1 | SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS | Interdict Bio, Inc. (US) | 2026-04-23 | — | — | US | disclosed |
| US-20260078116-A1 | SMALL MOLECULE PROTEIN SYNTHESIS MODULATORS | Interdict Bio, Inc. (US) | 2026-03-19 | — | — | US | disclosed |
| EP-4603105-A1 | PHARMACEUTICAL COMPOSITION CONTAINING CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT AGAINST HRAS AND NRAS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2025-08-20 | — | — | EP | disclosed |
| EP-4592308-A1 | CYCLIC COMPOUND HAVING SELECTIVE KRAS INHIBITORY EFFECT ON HRAS AND NRAS | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2025-07-30 | — | — | EP | disclosed |
| US-20250213555-A1 | SUBSTITUTED TETRAHYDROFURAN ANALOGS AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-07-03 | — | — | US | disclosed |
| CN-120202211-A | Cyclic compounds having selective KRAS inhibition over HRAS and NRAS | 中外制药株式会社 | 2025-06-24 | — | — | CN | disclosed |
| US-5578728-A | Process for the preparation of a benzo(a)quinolizione derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5561233-A | Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-10-01 | — | — | US | disclosed |
| US-5561233-A | Process for the preparation of an intermediate of a benzo[a]quinolizinone derivative | HOFFMANN-LA ROCHE INC. (US) | 1996-10-01 | — | — | US | disclosed |
| JP-H07188229-A | PREPARATION OF BENZO(A)QUINOLIZINONE DERIVATIVE | F HOFFMANN LA ROCHE AG | 1995-07-25 | — | — | JP | disclosed |
| EP-0650966-A1 | Process for the preparation of a benzo(a)quinolizinone derivative | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-03 | — | — | EP | disclosed |
| US-5326769-A | Treatment of sleep disorders | HOFFMANN-LA ROCHE INC. (US) | 1994-07-05 | — | — | US | disclosed |
| US-5281711-A | (S)-1-[10-chloro-6,7-dihydro-4-oxo-3-phenyl-4H-benzo[a]quino-lizin-1-yl)carbonyl]-3-ethoxypyrrolidine | HOFFMANN-LA ROCHE INC. (US) | 1994-01-25 | — | — | US | disclosed |
| US-4139632-A | Psychotropic 2-trifluoromethyl-10-[3-(3-hydroxy-pyrrolidino)-propyl]-phenothiazine compounds | EISAI CO., LTD. (JP) | 1979-02-13 | — | — | US | disclosed |