Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | TTR | P02766 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.35 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.35 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30353744 | 1.00 | TDP1 (0.41) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL29021770 | 0.92 | TDP1 (0.42) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL30353742 | 0.92 | TDP1 (0.42) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL29021594 | 0.91 | TDP1 (0.41) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL30353743 | 0.91 | TDP1 (0.41) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL30396199 | 0.89 | KMT2A (0.39) | TDP1MAPTPOLBKMT2ALMNA | |
| SCHEMBL29561773 | 0.89 | LMNA (0.36) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL22832028 | 0.89 | LMNA (0.36) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL29021712 | 0.80 | TDP1 (0.36) | TDP1ALDH1A1MAPTPOLBKMT2A | |
| SCHEMBL30353776 | 0.80 | TDP1 (0.36) | TDP1ALDH1A1MAPTPOLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096710-A | 4-oxo-3, 4-dihydroquinazolinone compounds for the treatment of BRAF related diseases and disorders | 阿雷生物药品公司 | 2023-05-09 | — | — | CN | disclosed |