Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.46 |
| ▸ | BRD4 | O60885 | 5/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 5/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21178874 | 0.81 | RET (0.67) | RET | |
| SCHEMBL21178822 | 0.81 | RET (0.52) | RETBRD4SMYD3 | |
| SCHEMBL1585180 | 0.71 | BRD4 (0.52) | BRD4 | |
| SCHEMBL1585468 | 0.71 | HTR6 (0.40) | BRD4 | |
| SCHEMBL8175357 | 0.66 | KDR (0.36) | BRD4 | |
| SCHEMBL31246045 | 0.66 | HTR6 (0.48) | — | |
| SCHEMBL1772103 | 0.66 | HTR6 (0.48) | BRD4 | |
| SCHEMBL13539079 | 0.64 | BRD4 (0.37) | BRD4 | |
| SCHEMBL1800219 | 0.64 | BRD4 (0.48) | BRD4 | |
| SCHEMBL22333531 | 0.64 | CYP2C19 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111971286-B | Substituted pyrrolo [2,3-d ] pyrimidine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2023-04-14 | — | — | CN | disclosed |