Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 15/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
| ▸ | CLK2 | P49760 | 1/20 | 0.34 |
| ▸ | CLK3 | P49761 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29471212 | 0.95 | GRM4 (0.38) | RETGSK3BDYRK1AGRM4CLK2 | |
| SCHEMBL24316690 | 0.95 | GRM4 (0.38) | RETGSK3BDYRK1AGRM4CLK2 | |
| SCHEMBL26112024 | 0.92 | CREBBP (0.36) | RETGSK3BDYRK1ACLK2CLK3 | |
| SCHEMBL29471232 | 0.92 | RET (0.42) | RET | |
| SCHEMBL26548437 | 0.92 | RET (0.42) | RET | |
| SCHEMBL24316580 | 0.90 | RET (0.37) | RETCREBBP | |
| SCHEMBL29471231 | 0.89 | CREBBP (0.37) | RETCREBBPUSP30 | |
| SCHEMBL26108147 | 0.89 | CREBBP (0.37) | RETCREBBPUSP30 | |
| SCHEMBL30480849 | 0.88 | CREBBP (0.36) | RETCREBBPUSP30 | |
| SCHEMBL26113389 | 0.88 | CREBBP (0.36) | RETCREBBPUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116368128-A | Heterocyclic compounds as CBP/EP300 bromodomain inhibitors | 奥瑞基尼肿瘤有限公司 | 2023-06-30 | — | — | CN | disclosed |