Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | NAMPT | P43490 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4112788 | 0.80 | NPC1 (0.71) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL29986357 | 0.80 | NPC1 (0.67) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL31054249 | 0.79 | NPC1 (1.00) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL651929 | 0.79 | NPC1 (1.00) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL1568786 | 0.78 | PABPC1 (0.65) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL257596 | 0.78 | NPC1 (0.65) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL30741445 | 0.78 | NPC1 (0.79) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL4890353 | 0.78 | NPC1 (0.79) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL29409612 | 0.77 | NPC1 (0.59) | NPC1POLBMEN1KMT2AMAPT | |
| SCHEMBL850424 | 0.77 | NPC1 (0.59) | NPC1POLBMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116217478-A | Synthesis method of 6-amino-3-difluoromethyl quinoline | 苏州康润医药有限公司 | 2023-06-06 | — | — | CN | claimed |
| CN-116217478-A | Synthesis method of 6-amino-3-difluoromethyl quinoline | 苏州康润医药有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-116217478-A | Synthesis method of 6-amino-3-difluoromethyl quinoline | 苏州康润医药有限公司 | 2023-06-06 | — | — | CN | disclosed |