Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29033596 | 0.80 | GRIN2B (0.54) | GRIN2BPOLBKMT2AMTNR1AMTNR1B | |
| SCHEMBL30479468 | 0.80 | GRIN2B (0.54) | GRIN2BPOLBKMT2AMTNR1AMTNR1B | |
| SCHEMBL29033601 | 0.76 | NAMPT (0.59) | GRIN2BPOLBKMT2AMTNR1AMTNR1B | |
| SCHEMBL30479478 | 0.76 | NAMPT (0.59) | GRIN2BPOLBKMT2AMTNR1AMTNR1B | |
| SCHEMBL10399460 | 0.72 | MTNR1A (0.51) | GRIN2BMTNR1AMTNR1BSIGMAR1CA1 | |
| SCHEMBL4043115 | 0.72 | GRIN2B (0.57) | GRIN2BMTNR1AMTNR1BSIGMAR1CA1 | |
| Hydrochloric Acid SCHEMBL4053518 | 0.70 | GRIN2B (0.56) | GRIN2BMTNR1AMTNR1BSIGMAR1CA1 | |
| SCHEMBL7095594 | 0.70 | ADRB3 (0.46) | CA1CA2 | |
| SCHEMBL10399768 | 0.69 | TAOK1 (0.55) | GRIN2BPOLBKMT2ASIGMAR1 | |
| SCHEMBL28583286 | 0.69 | CA1 (0.48) | GRIN2BMTNR1AMTNR1BSIGMAR1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116444517-B | Carboxamide compound and application thereof in preparation of deubiquitinase USP28 inhibitor | 苏州大学 | 2024-06-21 | — | — | CN | disclosed |
| CN-116444517-A | Carboxamide compound and application thereof in preparation of deubiquitinase USP28 inhibitor | 苏州大学 | 2023-07-18 | — | — | CN | disclosed |