SCHEMBL29035948

SCHEMBL29035948

O=C(F)C(Br)(Br)c1ccc(Br)cc1.O=C(c1cccc(Cl)c1)C(F)(Br)Br

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.40
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
ALDH1A1 P00352 3/20 0.39
MAPT P10636 3/20 0.39
LMNA P02545 2/20 0.38
HTT P42858 2/20 0.38
GAA P10253 1/20 0.38
SMN1; SMN2 Q16637 2/20 0.36
NPC1 O15118 1/20 0.36
KCNK3 O14649 1/20 0.36
KCNK9 Q9NPC2 1/20 0.36
ACHE P22303 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29035945 0.83 PARP1 (0.55) PARP1MEN1KMT2AALDH1A1MAPT
SCHEMBL18932760 0.72 PARP1 (0.46) PARP1MEN1KMT2AALDH1A1MAPT
SCHEMBL29791495 0.71 ACHE (0.58) PARP1ALDH1A1MAPTLMNAHTT
SCHEMBL111125 0.71 ACHE (0.58) PARP1ALDH1A1MAPTLMNAHTT
SCHEMBL31332687 0.71 PARP1 (0.49) PARP1MEN1KMT2AALDH1A1MAPT
SCHEMBL9315494 0.70 PARP1 (0.55) PARP1ALDH1A1MAPTLMNAHTT
SCHEMBL29035964 0.69 MIF (0.45) MEN1KMT2AALDH1A1MAPTLMNA
SCHEMBL4812828 0.69 PARP1 (0.53) PARP1MEN1KMT2AALDH1A1MAPT
SCHEMBL28507305 0.69 PARP1 (0.53) PARP1ALDH1A1MAPTLMNAHTT
SCHEMBL20639885 0.68 GRM5 (0.42) PARP1MEN1KMT2AALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115231995-A Mono-fluoro dibromo acetone derivative and preparation and application thereof 上海应用技术大学 2022-10-25 CN claimed
CN-115231995-A Mono-fluoro dibromo acetone derivative and preparation and application thereof 上海应用技术大学 2022-10-25 CN disclosed