SCHEMBL29035974

SCHEMBL29035974

O=C(c1ccccc1-c1ccccc1)C(F)(Br)Br

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCAT2 O15382 1/20 0.55
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
CHRNB2 P17787 2/20 0.49
CHRNB4 P30926 2/20 0.49
CHRNA3 P32297 2/20 0.49
CHRNA4 P43681 2/20 0.49
HNF4A P41235 1/20 0.47
HTT P42858 3/20 0.46
TSHR P16473 1/20 0.46
RECQL P46063 1/20 0.46
TACR1 P25103 2/20 0.46
FABP3 P05413 1/20 0.43
FABP4 P15090 1/20 0.43
FABP5 Q01469 1/20 0.43
ALDH1A1 P00352 3/20 0.43
TP53 P04637 1/20 0.43
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL307520 0.86 BCAT2 (0.57) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
SCHEMBL28774592 0.86 BCAT2 (0.61) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
SCHEMBL8661307 0.81 MEN1 (0.59) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
SCHEMBL5163372 0.81 CES1 (0.50) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
SCHEMBL13543201 0.80 BCAT2 (0.59) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
Trifluoroacetic Acid SCHEMBL16720000 0.77 HNF4A (0.56) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
SCHEMBL27627382 0.77 BCAT2 (0.55) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
SCHEMBL6721086 0.76 BCAT2 (0.53) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
SCHEMBL11599752 0.76 BCAT2 (0.53) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2
SCHEMBL11307451 0.75 BCAT2 (0.63) BCAT2MEN1KMT2ASMN1; SMN2CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115231995-A Mono-fluoro dibromo acetone derivative and preparation and application thereof 上海应用技术大学 2022-10-25 CN disclosed