Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 5/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.53 |
| ▸ | CCND1 | P24385 | 1/20 | 0.53 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.53 |
| ▸ | SRC | P12931 | 6/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | HCK | P08631 | 1/20 | 0.50 |
| ▸ | INSR | P06213 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037826 | 0.88 | LCK (0.56) | TNK2LCKMAPK14CDK4CCND1 | |
| SCHEMBL29037770 | 0.86 | FGFR1 (0.58) | TNK2LCKMAPK14FGFR1INSR | |
| SCHEMBL29037757 | 0.84 | CDK6 (0.59) | LCKMAPK14CDK4CCND1CDK6 | |
| SCHEMBL29037685 | 0.83 | ALK (0.59) | TNK2LCKMAPK14CDK4CCND1 | |
| SCHEMBL29037767 | 0.81 | SIK1 (0.62) | TNK2SRCEGFRBRD4 | |
| SCHEMBL29037691 | 0.81 | JAK3 (0.57) | TNK2LCKMAPK14FGFR1INSR | |
| SCHEMBL29037747 | 0.81 | EGFR (0.65) | FGFR1EGFR | |
| SCHEMBL29037725 | 0.80 | ALK (0.57) | TNK2LCKMAPK14CDK4CCND1 | |
| SCHEMBL29037788 | 0.80 | LCK (0.62) | LCKMAPK14CDK4CCND1SRC | |
| SCHEMBL29037703 | 0.78 | MAPK8 (0.59) | TNK2LCKMAPK14SRCALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |