Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 4/20 | 0.56 |
| ▸ | SRC | P12931 | 7/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 4/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | HCK | P08631 | 1/20 | 0.50 |
| ▸ | CTSC | P53634 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | BLK | P51451 | 1/20 | 0.47 |
| ▸ | BMX | P51813 | 1/20 | 0.47 |
| ▸ | JAK3 | P52333 | 1/20 | 0.47 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520500 | 0.84 | SRC (0.58) | SRCFGFR1LCKMAPK14HCK | |
| SCHEMBL29037859 | 0.81 | F10 (0.47) | SRCLCKBRD4JAK2JAK3 | |
| SCHEMBL29037788 | 0.78 | LCK (0.62) | SRCFGFR1LCKMAPK14KDR | |
| SCHEMBL31612051 | 0.78 | SYK (0.63) | SRCFGFR1LCKMAPK14HCK | |
| SCHEMBL29076271 | 0.78 | SYK (0.63) | SRCFGFR1LCKMAPK14HCK | |
| SCHEMBL31612095 | 0.76 | SYK (0.64) | SRCFGFR1LCKMAPK14HCK | |
| SCHEMBL29037855 | 0.76 | LCK (0.59) | SRCFGFR1LCKMAPK14KDR | |
| SCHEMBL4499760 | 0.75 | MAP3K7 (0.60) | SRCFGFR1LCKMAPK14KDR | |
| SCHEMBL30962725 | 0.74 | SRC (0.64) | SRCFGFR1LCKMAPK14KDR | |
| SCHEMBL27313555 | 0.74 | SRC (0.64) | SRCFGFR1LCKMAPK14KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |