Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.58 |
| ▸ | LCK | P06239 | 1/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.57 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.57 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | HCK | P08631 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | BLK | P51451 | 1/20 | 0.54 |
| ▸ | BMX | P51813 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 6/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29037788 | 0.92 | LCK (0.62) | SRCLCKMAPK14ALKFGFR1 | |
| SCHEMBL29037855 | 0.89 | LCK (0.59) | SRCLCKMAPK14ALKFGFR1 | |
| SCHEMBL29037685 | 0.85 | ALK (0.59) | SRCLCKMAPK14ALKFGFR1 | |
| SCHEMBL29037829 | 0.84 | FGFR3 (0.56) | SRCLCKMAPK14FGFR1HCK | |
| SCHEMBL29076271 | 0.82 | SYK (0.63) | SRCLCKMAPK14ALKFGFR1 | |
| SCHEMBL31612051 | 0.82 | SYK (0.63) | SRCLCKMAPK14ALKFGFR1 | |
| SCHEMBL29520635 | 0.81 | BRD4 (0.54) | SRCLCKMAPK14FGFR1MAP3K7 | |
| SCHEMBL31612095 | 0.81 | SYK (0.64) | SRCLCKMAPK14ALKFGFR1 | |
| SCHEMBL29037688 | 0.80 | LCK (0.70) | SRCLCKMAPK14ALKFGFR1 | |
| SCHEMBL4499760 | 0.80 | MAP3K7 (0.60) | SRCLCKMAPK14ALKFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |