Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 9/20 | 0.47 |
| ▸ | WEE1 | P30291 | 2/20 | 0.47 |
| ▸ | JAK3 | P52333 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29520635 | 0.83 | BRD4 (0.54) | JAK3JAK2TNK2SRCFLT3 | |
| SCHEMBL29037829 | 0.81 | FGFR3 (0.56) | JAK3JAK2SRCBRD4LCK | |
| SCHEMBL29076115 | 0.71 | SIK1 (0.73) | JAK3JAK2TNK2BRD4JAK1 | |
| SCHEMBL31612120 | 0.71 | SIK1 (0.73) | JAK3JAK2TNK2BRD4JAK1 | |
| SCHEMBL12322726 | 0.69 | STAT6 (0.58) | WEE1JAK3JAK2FLT3JAK1 | |
| SCHEMBL31612069 | 0.69 | SIK1 (0.81) | TNK2SRCBRD4 | |
| SCHEMBL29076110 | 0.69 | SIK1 (0.81) | TNK2SRCBRD4 | |
| SCHEMBL29037805 | 0.67 | FGFR3 (0.53) | WEE1BRD4LCK | |
| SCHEMBL9976505 | 0.67 | F10 (0.79) | F10 | |
| SCHEMBL4507547 | 0.67 | LCK (0.63) | JAK3TNK2SRCBRD4LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |