Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4384007 | 0.86 | ALDH1A1 (0.46) | SIGMAR1ABCB1ABCG2HTTMEN1 | |
| SCHEMBL2908554 | 0.81 | KMT2A (0.48) | SIGMAR1HTR2AKCNH2MEN1KMT2A | |
| SCHEMBL2903285 | 0.81 | LMNA (0.50) | SIGMAR1HTTMEN1KMT2APOLB | |
| SCHEMBL2910357 | 0.80 | SMN1; SMN2 (0.52) | HTTMEN1KMT2APOLB | |
| SCHEMBL2908214 | 0.80 | ALDH1A1 (0.47) | HTT | |
| SCHEMBL2908712 | 0.80 | ALDH1A1 (0.50) | HTTMEN1KMT2APOLB | |
| SCHEMBL2902110 | 0.78 | HTT (0.43) | HTTKMT2APOLB | |
| SCHEMBL2905409 | 0.78 | MEN1 (0.61) | HTTMEN1KMT2APOLB | |
| SCHEMBL2906383 | 0.78 | MAPT (0.53) | DRD2HTTMEN1KMT2APOLB | |
| SCHEMBL2903473 | 0.78 | HTT (0.49) | SIGMAR1HTTMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041104-B1 | CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR USE AS PAR- I ANTAGONISTS | PF MEDICAMENT (FR) | 2010-08-18 | — | — | EP | disclosed |